Simian virus 40 (SV40)

Mesothelioma on

Saturday 4 April 2015

Malignant mesothelioma has long been associated with exposure to asbestos. The end of this century, thousands of cases of the disease found in individuals who work regularly with toxic minerals in a variety of different jobs. But nevertheless report released about 30 years ago by McDonald and McDonald determined that approximately 25-33 percent of all cases of mesothelioma cancer diagnosis has no definite relationship with exposure to asbestos. Someone who has been diagnosed with mesothelioma cancer is never any contact with asbestos or asbestos-containing material.

For years researchers have discovered several other potential causes for the cause of the growth of mesothelioma. One of the patients with mesothelioma may be exposed to simian virus 40 (SV40).

• Does SV40?

SV40 is a virus that was first discovered in 1960. The virus is found in the kidney cells of rhesus monkeys. It causes kidney disease and certain cancers in the monkey population. This virus also attacks certain tumor suppressor genes and cell death.

Simian Virus 40 US public concern when it is certain that the kidney cells of rhesus monkeys are the same used in the manufacture of the polio vaccine given to humans. This vaccine has been used from 1958 until 1963 and was given to nearly 100 million Americans. There is a considerable amount of contaminated vaccine Simian Virus 40 and given to humans during that time period. Although exact figures are not recorded how many doses of virus contamination is given, but estimated between 10 to 30 million doses.

• SV40 and Mesothelioma

Since the discovery of the Simian virus 40 in millions of doses of polio vaccine, researchers have been exploring the relationship between viruses and cancer development in humans. Some studies have found that SV40 is present in many people who are diagnosed with mesothelioma disease.

A study led by Dr. Michele Carbone mesothelioma is one of the leading specialists in the US, established that more than half (about 54%) of all cases of malignant mesothelioma cancer has been infected with SV40 (Carbone, M. "Simian virus 40 and human tumors: It is time to study mechanisms. "). But they did not find the SV40 contamination in other types of lung cancer. This reinforces the finding that there is a relationship between SV40 and asbestos cancer, but there is no full proof that only the SV40 alone that causes mesothelioma. The doctor gave the hypothesis that exposure to asbestos or immunosuppression may also be involved in this case.

A similar study conducted in 2008 at the Cancer Research Center of Hawaii and the Department of Pathology, University of Hawaii, concluded that about 60 percent of hamsters inoculated with Simian Virus 40 intracardiac died of mesothelioma. However, the significant role of SV40 against malignant mesothelioma in humans remains debatable (Rivera et al, "The Relationship between Simian Virus 40 and Mesothelioma"). The short conclusion the authors reported: "There is sufficient evidence on the relationship between the simian virus 40 alone or together asbestos as a trigger for malignant mesothelioma. However, it is still not enough to speculate about the contribution of simian virus 40 with pleural mesothelioma overall incidence (pleural mesothelioma chest). "

• SV40 and Asbestos

Additional studies noted that the combination of the presence of SV40 and asbestos exposure is very often the case in improving development opportunities mesothelioma. In a 2005 report by a number of physicians and scientists Italy (Cristaudo et al, "SV40 enhances the Risk of Malignant Mesothelioma Among People Exposed to Asbestos: A Molecular Epidemiologic Case-Control Study"), the authors hypothesize that SV40 contributes to cancer development only as an additional factor and not a direct cause.

More importantly, the study determined that "the detection of SV40 between groups of individuals exposed to asbestos could represent a useful marker for identifying those at high risk for MM (Malignant Mesothelioma - Malignant mesothelioma). The subgroup of high-risk individuals can be monitored for early detection and possibility of curative surgical excision ".

Most doctors are constantly looking for better ways to diagnose mesothelioma in early stages, karenan identify high-risk individuals such as this equates to save many lives.

Labels: Medicine, Mesothelioma, Mesothelioma Epidemiology

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